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Detection and monitoring of human bocavirus 1 infection by a new rapid antigen test

A. H. L. Bruning1 , P. Susi2 , H. Toivola3 , A. Christensen4 , M. Söderlund-Venermo5 , K. Hedman5 , H. Aatola3 , A. Zvirbliene6 and J. O. Koskinen3

1) Department of Pediatric Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, Amsterdam, The Netherlands, 2) Department of Virology, University of Turku and Biomaterials and Diagnostics Group, Turku University of Applied Sciences, 3) ArcDia International Oy Ltd., Turku, Finland, 4) Trondheim University Hospital and Norwegian University of Science and Technology, Trondheim, Norway, 5) Department of Virology, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland and 6) Department of Immunology and Cell Biology, Institute of Biotechnology, Vilnius University, Lithuania

New Microbes New Infect. May 2016, doi:10.1016/j.nmni.2016.01.015

ABSTRACT
Clinically relevant diagnosis of human bocavirus 1 (HBoV1) is challenging, as the virus is frequently detected in asymptomatic patients, and cofindings with other respiratory viruses are common. The clinical value of current diagnostic methods, such as PCR, is therefore low, and alternative diagnostic strategies are needed. We describe for the first time the use of an antigen detection assay for the rapid identification of HBoV1 in a paediatric patient with respiratory tract infection symptoms. We estimate the duration of active HBoV1 infection to be 6 days.